长春市卫生系统反应性与居民满意度现况调查分析

目的了解长春市卫生系统反应性及居民满意度现况,以期为卫生服务体系建立与完善提供科学依据。方法采用多阶段分层整群随机抽样方法对长春市城乡居民卫生服务现状进行问卷调查。结果对就诊医院、就诊设施表示不满意：城市（42．53％）高于农村（35．57％）;对社区卫生服务满意度总体评价为17．77％,住院患者（16．76％）对医生信任程度略低于门诊病人。城市不信任比例明显高于农村居民。结论加大卫生服务保障力度,医疗卫生机构合理布局,加强医患沟通交流,为城乡居民提供规范、完善的医疗卫生服务是满足长春市居民卫生服务需求与发展的重要措施。     

Isolation and Identification of Naegleria Species from Environmental Water in Changchun,Northeastern China

Background

Naegleria is a free-living amoeba, and pathogenic Naegleria may pose a health risk to people exposed to recreational water. Our objective in this study was to determine if there are pathogenic amoebae in environmental water samples from Changchun, Northeastern China.

Methods

During July to September 2012, a total of 70 water samples were collected from Changchun, Northeastern China, and Naegleria was enriched by in vitro culture and detected by PCR using Naegleria genus-specific primers. Resulting PCR products were sequenced and phylogenetically analyzed to identify Naegleria species.

Results

Naegleria was detected in 65 (92.9%) of 70 water samples. DNA sequence and phylogenetic analyses based on the internal transcribed spacer (ITS) rDNA sequences revealed four Naegleria species, including N. pagei (n = 24) and N. Australiensis (n = 18), N. clarki (n = 13) and N. gruberi (n = 10), in which N. australiensis is pathogenic to mice. But the pathogenic species N. fowleri was not detected.

Conclusion

This is the first report on Naegleria species in Northeastern China, showing that almost all environmental water samples were contaminated with Naegleria, including N. pagei, N. Australiensis, N. clarki and N. gruberi, which should be considered a potential public health threat.     

长春市市售蔬菜寄生虫卵污染情况调查

目的 了解长春市市售蔬菜寄生虫卵感染情况。方法 随机在长春市4个蔬菜市场采集10种蔬菜。每种蔬菜采集样本15份，每份200g，蒸馏水清洗，用标准筛分层过滤，洗液离心取底部沉渣镜检。结果 检查10种蔬菜，3种发现有蛔虫卵，3种发现有肝吸虫卵，6种发现有犬钩虫卵。150份标本中，36份阳性，阳性率为24％。其中韭菜感染率最高，依次是小白菜、葱。结论 长春市市售蔬菜总体感染率较高，居民生吃蔬菜有感染寄生虫的机会。     

魏跃钢教授治疗扁平疣经验总结

[目的]总结魏跃钢教授治疗扁平疣的临床经验。[方法]通过跟师随诊,搜集魏跃钢教授临床治疗扁平疣的案例并查阅文献,分析魏教授对扁平疣病因病机的认识,总结魏教授治疗扁平疣的临床经验,并举案例一则以佐证。[结果]魏跃钢教授认为临床发为本病者多挟热邪,以素体肝郁为本,瘀血为主要病理产物,故主张从热论治,以清热解毒为治疗大法,重视调肝,兼以活血。所举案例以此法为要,以马齿苋合剂为基础方,清热解毒兼以行气活血,疗效显著。[结论]魏跃钢教授从热论治扁平疣疗效显著,其经验值得借鉴。     

The effect of Qinggong Changchun Capsule (6E05;5BAB;957F;6625;4E39;) on decreased fluid intelligence associated with aging

A test was carried out to evaluate. the effect of Qingong Changchun capsule on decreased fluid intelligence associated with aging. Nootropil and a placebo were used as the control drugs. Random, single-blind and self-control observation methods were applied. Ninety days were spent for clinical study. One hundred and fifty-four elderly subjects were divided into three groups (Test 63, nootropil 60, placebo 31). The method of measuring intelligence was gauged by communication between subject and computer. The measure included eight parameters. The main results were as follows: In the test group, there were significant differences (P<0.01) in speed of calculation (5.9±2.5 s, 5.1±2.1 s), speed of digits and pictures (24.2±6.2 s, 21.7±6.7 s), two-digit span (2.8±1.0, 3.2±0.8) and another two parameters before and after treatment. In the nootropil group, some parameters were also improved significantly. But in the normal control there was not any evident change. The results suggest that the treatment is an effective therapy for decreased fluid intelligence with aging.     

高效液相色谱法测定瑞巴匹特血浆浓度

目的 :建立测定血浆内瑞巴匹特浓度的高效液相色谱法。方法 :KromasilC18色谱柱 ,甲醇 -0 .0 5mol·L- 1磷酸二氢钾 (55∶45,pH3.0 )为流动相 ,并由序贯单纯形法确定此为最佳配比点 ,流速 1 .0ml·min- 1,检测波长 2 30nm。结果 :瑞巴匹特在 1 5～ 1 2 0 0 μg·L- 1范围内 ,血浆药物浓度C与色谱峰高H呈现良好线性相关 ,血浆中瑞巴匹特平均相对回收率为(97.5± 0 .5) %(n =5) ,平均绝对回收率为 (90 .3± 1 .8) %(n =5) ;平均日内和日间RSD分别为 4.6 8%和 5.6 6 %(n =5) ;方法对血浆瑞巴匹特最低检出浓度为 2 μg·L- 1。结论 :本方法适于血浆中瑞巴匹特的测定。     

基于运气理论探讨长春地区颈椎病发病与体质的相关性研究

目的 探讨长春地区颈椎病患者发病与体质的相关性,为颈椎病的防治提供新思路.方法 选取2019年2月—2021年4月期间长春中医药大学附属医院收治的颈椎病患者3322例患者.收集3322例颈椎病患者出生时的五运六气资料,年龄跨度80余年,统计岁运/司天/在泉运气合参的分布特征,进行描述性统计、卡方检验.结果 岁运/司天/...     

浙江金华医家魏祖清及其著作考略

[目的]考证浙江金华医家魏祖清生平，并对其著作的版本、流传以及内容进行整理研究。[方法]采用文献研究法结合田野调查法，检索史志、地方志、目录工具书并结合实地调研，对魏氏人物生平进行考证，整理研究其著作文献，归纳其学术思想特点。[结果]清中期浙江金华汤溪医家魏祖清，儒道医理皆通，以医行于世，有《村居急救方》《卫生编》《树蕙编》《千金方翼注》《保产机要》等著作，其中后两部著作已佚，前三部著作的清刻本馆藏于苏州、常州、北京、上海等地。魏氏在养生、求嗣、方书等方面颇有建树，结合其著作可将其学术思想归纳为儒道结合重养生、求简务实擅急救、擅制膏丹(丸)名京师。[结论]魏祖清是清中期浙江金华著名医家，儒医皆通，擅养生、求嗣、方书等，其学术著作丰富，流传广泛，反映了当时金华地方中医学特色。     

Functional variants of TNFAIP3 are associated with systemic lupus erythematosus in a cohort of Chinese Han population

Tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) is a negative regulator of NF-κB activity. We previously reported that the paired tandem polymorphic dinucleotides TT > A (rs148314165, rs200820567 of TNFAIP3) conferred the risk for systemic lupus erythematosus (SLE) in European and Korean populations. We investigated the genetic association of the TT > A variants, as well as the functional coding variant rs2230926 in exon 3 of TNFAIP3 in 1229 Chinese Han SLE patients and 1608 matched population controls. We further evaluated the role of these variants in regulating expression of the TNFAIP3 gene and NF-κB signaling pathway in their peripheral blood mononuclear cells from Chinese SLE patients. The TT > A variants and the TNFAIP3 exon 3 coding variant rs2230926 demonstrated significant associations in SLE (P_{TT > A} = 8.96 × 10^?12, odds ratio [OR] = 2.07, 95% confidence interval [CI] = 1.68–2.55). SLE patients carrying the risk A allele showed reduced messenger RNA expression of the TNFAIP3 gene and increased expression of NF-κB1 in PBMCs. Conditional analyses revealed that the TT > A variants are likely to be causal variants in Chinese Han SLE patients. The TT > A variants associated with Chinese Han SLE and negatively regulate the expression of the TNFAIP3 gene resulting in enhanced NF-κB activity.     

Two rare cases of maxillary pneumocoele

Pathological expansion of the paranasal sinus by air is rare, and may cause severe deformation of the overlying bone and tissue. We present two cases of young adults with maxillary pneumocoeles that were diagnosed by computed tomography, and discuss the differential aetiology.